2019 ESOC | an optimal level of early systolic blood pressure control in acute stroke due to intracerebral haemorrhage was found

In 2019, the 5th European Stroke Organization Conference (ESOC) was held in Milan, Italy during 22 to 24 May.

ESOC 2019 saw presentations of major clinical trials, state-of-the-art talks by renowned clinicians and researchers, and updates on the latest guidelines were highlighted. Several members of The George Institute China, led by Executive Director Professor Craig Anderson, were invited to the conference and made keynote speeches and poster communications.  

Professor Anderson’s doctoral fellow, Dr Tom Moullaali, who is based in Edinburgh, Scotland, gave a keynote speech to show that early and sustained lowering of systolic blood pressure (BP) to levels much lower than have previously been considered, less than 130 mmHg (millimetres of mercury), in patients with acute intracerebral haemorrhage (ICH) provides the best chance of surviving and ensuring good recovery from this devastating condition.

“There has been controversy from apparent different findings of the two largest trials of rapid BP lowering in ICH - INTERACT2, which I led, and ATACH-II, organized by my United States colleagues.  This has caused doubt about the effectiveness of intensive BP lowering as a treatment for acute ICH.  So, we joined forces to pool our study data and try and resolve areas of ongoing uncertainty,” Professor Anderson said.

The study was a prospective analysis of a total of 3829 patients with ICH and elevated systolic BP who participated in large INTERACT2 and ATACH-II trials investigating intensive BP treatment. 

The new pooling project study found significant beneficial associations of early intensive BP reduction and clinical outcomes after ICH, which extends previous analyses and identified an optimal systolic BP level of 120-130 mmHg for best recovery, which is lower than previously considered for recommendations that have been made in various clinical guidelines around the world. 

Research to guide clinical practice is a mission of The George Institute, recognized by experts at home and abroad, and aroused positive discussion among participants at the conference.